The influence of irradiation wavelength and intensity on photochemistry of acetaminophen(-)(APAP) in aqueous solution was investigated by combination of steady-state and laser flash photolysis as well as HPLC and LC-MS. Steady-state irradiation at 254 nm leads to APAP disappearance with the quantum yield 0.0014 and to formation of 1-(2-amino-5-hydroxyphenyl)ethanone (P1) as a main primary photo-Fries product. In opposite the laser excitation at 266 nm leads predominantly to two-photon ionization of APAP with the quantum yield 0.013 (1=70 mJ/cm(2)) and to the formation of one main product of phenoxyl radical reactions - N-(3,4-dihydroxyphenyl)acetamide (P5). Steady-state excitation at 282 nm leads to both P1 and P5 products formation indicating competition of photo-Fries and photoionization processes. The wavelength-dependent mechanism of APAP photolysis is proposed and discussed. (C) 2013 Elsevier B.V. All rights reserved.
|Журнал||Journal of Photochemistry and Photobiology A: Chemistry|
|Состояние||Опубликовано - 30 янв 2014|
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