Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model

S. N. Shchelkunov; I. A. Razumov; I. V. Kolosova; A. V. Romashchenko; E. L. Zavjalov

doi:10.1134/S1607672918010088

Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model

S. N. Shchelkunov, I. A. Razumov, I. V. Kolosova, A. V. Romashchenko, E. L. Zavjalov

Кафедра молекулярной биологии и биотехнологии

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

3 Цитирования (Scopus)

Аннотация

The possibility of glioblastoma virotherapy at intravenous injection of the LIVP–GFP recombinant virus was studied in experimental model of orthotopic xenotransplantation of human glioblastoma cell line U87 to SCID laboratory mice. The LIVP–GFP recombinant virus deficient for thymidine kinase exhibited a significantly greater oncolytic capacity than the original LIVP virus, and an intravenous injection of LIVP–GFP at the early stages of tumorigenesis in mouse brain in most cases resulted in the lysis of the tumor.

Язык оригинала	английский
Страницы (с-по)	30-33
Число страниц	4
Журнал	Doklady Biochemistry and Biophysics
Том	478
Номер выпуска	1
DOI	https://doi.org/10.1134/S1607672918010088
Состояние	Опубликовано - 1 янв 2018

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10.1134/S1607672918010088

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Подробные сведения о темах исследования «Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model». Вместе они формируют уникальный семантический отпечаток (fingerprint).

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abstract = "The possibility of glioblastoma virotherapy at intravenous injection of the LIVP–GFP recombinant virus was studied in experimental model of orthotopic xenotransplantation of human glioblastoma cell line U87 to SCID laboratory mice. The LIVP–GFP recombinant virus deficient for thymidine kinase exhibited a significantly greater oncolytic capacity than the original LIVP virus, and an intravenous injection of LIVP–GFP at the early stages of tumorigenesis in mouse brain in most cases resulted in the lysis of the tumor.",

author = "Shchelkunov, {S. N.} and Razumov, {I. A.} and Kolosova, {I. V.} and Romashchenko, {A. V.} and Zavjalov, {E. L.}",

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Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model. / Shchelkunov, S. N.; Razumov, I. A.; Kolosova, I. V.; Romashchenko, A. V.; Zavjalov, E. L.

В: Doklady Biochemistry and Biophysics, Том 478, № 1, 01.01.2018, стр. 30-33.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Romashchenko, A. V.

AU - Zavjalov, E. L.

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