Labor migration is a social phenomenon that is accompanied by many positive and negative aftermaths. One of the negative aftermaths of migration is a strong increase in inclination to mental disorders among migrants. The high development rate of computer technology made it possible to carry out diagnostic measures for somatic and mental diseases in more detail. A widespread method of electrophysiological studies of the human central nervous system is registration of fluctuations in the electrical potentials of the brain from the surface of the skull-electroencephalogram (EEG). Today EEG is a reliable tool for explaining psychological phenomena and human behavior. We used this method to study the changes in the so-called default mode network of the brain (the brain in a state of calm wakefulness) in the processes of adaptation of labor migrants to extreme climate conditions. The article aims to study the relationship between functional changes in the electrophysiological activity of the default mode network with the risk of developing affective pathologies of various origins in labor migrants in the region of the Republic of Sakha (Yakutia) in the process of their adaptation to new climatic and social conditions.