Understanding sex differences in zebrafish pain- and fear-related behaviors

Leticia Marcon, Ana C.V.V. Giacomini, Bruna E. dos Santos, Fabiano Costa, Denis B. Rosemberg, Konstantin A. Demin, Allan V. Kalueff, Murilo S. de Abreu

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Sex is an important variable in translational biomedical research. While overt sex differences have been reported for pain and fear-like behaviors in humans and rodents, these differences in other popular model organisms, such as zebrafish, remain poorly understood. Here, we evaluate potential sex differences in zebrafish behavioral responses to pain (intraperitoneal administration of 5% acetic acid) and fear stimuli (exposure to alarm substance). Overall, both male and female zebrafish exposed to pain (acetic acid injection) show lesser distance traveled, fewer top entries and more writhing-like pain-related behavior vs. controls, whereas female fish more robustly (than males) altered some other pain-like behaviors (e.g., increasing freezing episodes and time in top) in this model. In contrast, zebrafish of both sexes responded equally strongly to fear evoked by acute alarm substance exposure. Collectively, these findings emphasize the growing importance of studying sex differences in zebrafish behavioral and pain models.

Язык оригиналаанглийский
Номер статьи136412
Страницы (с-по)136412
ЖурналNeuroscience Letters
Том772
Ранняя дата в режиме онлайн20 дек. 2021
DOI
СостояниеОпубликовано - 16 февр. 2022

Предметные области OECD FOS+WOS

  • 3.01 ФУНДАМЕНТАЛЬНАЯ МЕДИЦИНА
  • 3.01.RU НЕЙРОБИОЛОГИЯ
  • 3.02.RT КЛИНИЧЕСКАЯ НЕВРОЛОГИЯ

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