Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

Murilo S. de Abreu, Konstantin A. Demin, Ana C. V. V. Giacomini, Tamara G. Amstislavskaya, Tatyana Strekalova, Gleb O. Maslov, Yury Kositsin, Elena Petersen, Allan Kalueff

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.

Язык оригиналаанглийский
Номер статьи100405
Число страниц11
ЖурналNeurobiology of stress
Том15
DOI
СостояниеОпубликовано - ноя 2021

Предметные области OECD FOS+WOS

  • 3.01.RU НЕЙРОБИОЛОГИЯ
  • 3.02.RT КЛИНИЧЕСКАЯ НЕВРОЛОГИЯ

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