Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Svetlana A. Myz; Tatyana P. Shakhtshneider; Mikhail A. Mikhailenko; Andrey G. Ogienko; Ekaterina G. Bogdanova; Anna A. Ogienko; Svetlana A. Kuznetsova; Elena V. Boldyreva; Vladimir V. Boldyrev

doi:10.1177/1934578x1501000806

Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Svetlana A. Myz, Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Andrey G. Ogienko, Ekaterina G. Bogdanova, Anna A. Ogienko, Svetlana A. Kuznetsova, Elena V. Boldyreva, Vladimir V. Boldyrev

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

4 Цитирования (Scopus)

Аннотация

The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

Язык оригинала	английский
Страницы (с-по)	1345-1347
Число страниц	3
Журнал	Natural Product Communications
Том	10
Номер выпуска	8
DOI	https://doi.org/10.1177/1934578x1501000806
Состояние	Опубликовано - 2015

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10.1177/1934578x1501000806

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Myz, Svetlana A. ; Shakhtshneider, Tatyana P. ; Mikhailenko, Mikhail A. ; Ogienko, Andrey G. ; Bogdanova, Ekaterina G. ; Ogienko, Anna A. ; Kuznetsova, Svetlana A. ; Boldyreva, Elena V. ; Boldyrev, Vladimir V. / Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate. В: Natural Product Communications. 2015 ; Том 10, № 8. стр. 1345-1347.

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abstract = "The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.",

keywords = "Ball-milling, Betulin, Freeze-drying, Glycine, Polyethylene glycol, Solubilization",

author = "Myz, {Svetlana A.} and Shakhtshneider, {Tatyana P.} and Mikhailenko, {Mikhail A.} and Ogienko, {Andrey G.} and Bogdanova, {Ekaterina G.} and Ogienko, {Anna A.} and Kuznetsova, {Svetlana A.} and Boldyreva, {Elena V.} and Boldyrev, {Vladimir V.}",

year = "2015",

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Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate. / Myz, Svetlana A.; Shakhtshneider, Tatyana P.; Mikhailenko, Mikhail A.; Ogienko, Andrey G.; Bogdanova, Ekaterina G.; Ogienko, Anna A.; Kuznetsova, Svetlana A.; Boldyreva, Elena V.; Boldyrev, Vladimir V.

В: Natural Product Communications, Том 10, № 8, 2015, стр. 1345-1347.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

AU - Myz, Svetlana A.

AU - Shakhtshneider, Tatyana P.

AU - Mikhailenko, Mikhail A.

AU - Ogienko, Andrey G.

AU - Bogdanova, Ekaterina G.

AU - Ogienko, Anna A.

AU - Kuznetsova, Svetlana A.

AU - Boldyreva, Elena V.

AU - Boldyrev, Vladimir V.

PY - 2015

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KW - Ball-milling

KW - Betulin

KW - Freeze-drying

KW - Glycine

KW - Polyethylene glycol

KW - Solubilization

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