Two-step synthesis of monoterpenoid dioxinols exhibiting analgesic activity from isopulegol and benzaldehyde over heterogeneous catalysts

Martina Stekrova, Päivi Mäki-Arvela, Ewelina Leino, Karolina M. Valkaj, Kari Eränen, Atte Aho, Annika Smeds, Narendra Kumar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu Murzin

Результат исследования: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Аннотация

Benzodioxinols, compounds with 6-membered heterocycles containing two oxygen atoms, exhibit promising analgesic activity. In the current study, synthesis of dioxinol via two-step approach including Prins cyclization of isopulegol with benzaldehyde to tetrahydropyran and its ring-rearrangement to dioxinol was investigated. Different acidic and basic catalysts were studied in the second step and the highest selectivity toward dioxinol was achieved using mesoporous Ce-composite material.

Язык оригиналаанглийский
Страницы (с-по)56-62
Число страниц7
ЖурналCatalysis Today
Том279
DOI
СостояниеОпубликовано - 1 янв 2017

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    Stekrova, M., Mäki-Arvela, P., Leino, E., Valkaj, K. M., Eränen, K., Aho, A., Smeds, A., Kumar, N., Volcho, K. P., Salakhutdinov, N. F., & Murzin, D. Y. (2017). Two-step synthesis of monoterpenoid dioxinols exhibiting analgesic activity from isopulegol and benzaldehyde over heterogeneous catalysts. Catalysis Today, 279, 56-62. https://doi.org/10.1016/j.cattod.2016.03.046