Two-step synthesis of monoterpenoid dioxinols exhibiting analgesic activity from isopulegol and benzaldehyde over heterogeneous catalysts

Martina Stekrova, Päivi Mäki-Arvela, Ewelina Leino, Karolina M. Valkaj, Kari Eränen, Atte Aho, Annika Smeds, Narendra Kumar, Konstantin P. Volcho, Nariman F. Salakhutdinov, Dmitry Yu Murzin

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    4 Цитирования (Scopus)

    Аннотация

    Benzodioxinols, compounds with 6-membered heterocycles containing two oxygen atoms, exhibit promising analgesic activity. In the current study, synthesis of dioxinol via two-step approach including Prins cyclization of isopulegol with benzaldehyde to tetrahydropyran and its ring-rearrangement to dioxinol was investigated. Different acidic and basic catalysts were studied in the second step and the highest selectivity toward dioxinol was achieved using mesoporous Ce-composite material.

    Язык оригиналаанглийский
    Страницы (с-по)56-62
    Число страниц7
    ЖурналCatalysis Today
    Том279
    DOI
    СостояниеОпубликовано - 1 янв 2017

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