Аннотация
Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.
Язык оригинала | английский |
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Страницы (с-по) | 108-110 |
Число страниц | 3 |
Журнал | Doklady Biochemistry and Biophysics |
Том | 479 |
Номер выпуска | 1 |
DOI | |
Состояние | Опубликовано - 1 мар 2018 |