Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain

N. N. Dygalo, T. S. Kalinina, D. A. Lanshakov

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

Язык оригиналаанглийский
Страницы (с-по)108-110
Число страниц3
ЖурналDoklady Biochemistry and Biophysics
Том479
Номер выпуска1
DOI
СостояниеОпубликовано - 1 мар 2018

    Fingerprint

Цитировать