Towards reliable diagnostics of prostate cancer via breath

K. S. Maiti, E. Fill, F. Strittmatter, Y. Volz, R. Sroka, A. Apolonski

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.

Язык оригиналаанглийский
Номер статьи18381
ЖурналScientific Reports
Том11
Номер выпуска1
DOI
СостояниеОпубликовано - дек 2021

Предметные области OECD FOS+WOS

  • 3 МЕДИЦИНСКИЕ НАУКИ И ЗДРАВООХРАНЕНИЕ
  • 1.03 ФИЗИЧЕСКИЕ НАУКИ И АСТРОНОМИЯ
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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