Towards optical control of single blood platelet activation

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

Blood platelets play a pivotal role in blood coagulation and in other normal and pathological processes. The understanding of fundamental mechanisms underlying their functions is very important for diagnostics and treatment. Single-cell experiments are needed for this purpose, which are complicated by insufficient spatiotemporal precision of conventional activation protocols. We present an approach to trigger single platelet activation optically, without the need of reagent mixing. This is achieved using photolabile compound, which rapidly delivers epinephrine upon UV irradiation. We demonstrated the applicability of the technique to rapidly induce platelet activation for studying dynamics of activation. The presented method may give novel fundamental knowledge about platelet functions and facilitate current research of their ability to deliver drugs to tumors or vascular injury sites.

Язык оригиналаанглийский
Название основной публикацииSARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV
Подзаголовок основной публикацииLaser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV
РедакторыVL Derbov, DE Postnov
ИздательSPIE
Число страниц7
Том10717
ISBN (электронное издание)9781510620032
DOI
СостояниеОпубликовано - 1 янв 2018
СобытиеSaratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV - Saratov, Российская Федерация
Продолжительность: 26 сен 201730 сен 2017

Серия публикаций

НазваниеProceedings of SPIE
ИздательSPIE-INT SOC OPTICAL ENGINEERING
Том10717
ISSN (печатное издание)0277-786X

Конференция

КонференцияSaratov Fall Meeting 2017: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV
СтранаРоссийская Федерация
ГородSaratov
Период26.09.201730.09.2017

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    Spiryova, D. V., Karmatskih, O. Y., Vorob'Ev, A. Y., & Moskalensky, A. E. (2018). Towards optical control of single blood platelet activation. В VL. Derbov, & DE. Postnov (Ред.), SARATOV FALL MEETING 2017: LASER PHYSICS AND PHOTONICS XVIII; AND COMPUTATIONAL BIOPHYSICS AND ANALYSIS OF BIOMEDICAL DATA IV: Laser Physics and Photonics XVIII; and Computational Biophysics and Analysis of Biomedical Data IV (Том 10717). [1071722] (Proceedings of SPIE; Том 10717). SPIE. https://doi.org/10.1117/12.2305477