Time in Range Analysis and Glucose Variability in Type 1 Diabetic Patients with Different Stages of Chronic Kidney Disease

Natalia Myakina, Alla Vigel, Igor Lots

    Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

    Аннотация

    The aim: to assess the relationships between glucose variability (GV) parameters and renal function in patients with type 1 diabetes (T1D) at different stages of chronic kidney disease (CKD). Materials and Methods: We observed 127 patients with T1D, 48 M/79 F, from 18 to 72 years of age. Patients were divided into 5 groups: 1) no signs of CKD (CKD0), n=27; 2) CKD C1-C2, n=67; 3) CKD C3-C4, n=26; 5) CKD C5 (hemodialysis, n=7). Time in ranges and GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), 2-hour Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were derived from 72-hour continuous glucose monitoring. Results: As compared to patients without CKD, the values of MAGE, LI, HBGI were increased significantly in patients with CKD C1-C2 (all p<0.05). No differences were found in all GV parameters between CKD C3-C4 and CKD0 groups. In patients on hemodialysis time in hyperglycemic range, MAGE, LI, CONGA and HBGI were significantly higher as compared to other groups (all p<0.05). In patients with CKD C3-C5 there were negative correlations between HBGI, CONGA and estimated glomerular filtration rate (eGFR). In patients with eGFR >60 ml/min/1.73m2 HbA1c levels correlated positively with mean monitored glucose, time in hyperglycemic range, HBGI, CONGA, MAGE, LI, and MAG. On the contrary, in patients with lower eGFR none of GV parameters correlated with HbA1c. Conclusions: The results demonstrate non-linear relationships between eGFR and GV parameters in patients with T1D.

    Язык оригиналаанглийский
    Название основной публикации11th International Conference Bioinformatics of Genome Regulation and Structure\Systems Biology, BGRS\SB 2018 - Proceedings
    ИздательInstitute of Electrical and Electronics Engineers Inc.
    Страницы106-109
    Число страниц4
    ISBN (электронное издание)9781538668504
    DOI
    СостояниеОпубликовано - 26 ноя 2018
    Событие11th International Conference Bioinformatics of Genome Regulation and Structure\Systems Biology, BGRS\SB 2018 - Novosibirsk, Российская Федерация
    Продолжительность: 20 авг 201825 авг 2018

    Конференция

    Конференция11th International Conference Bioinformatics of Genome Regulation and Structure\Systems Biology, BGRS\SB 2018
    СтранаРоссийская Федерация
    ГородNovosibirsk
    Период20.08.201825.08.2018

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