Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease

Elena Kutumova, Ilya Kiselev, Ruslan Sharipov, Galina Lifshits, Fedor Kolpakov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.

Язык оригиналаанглийский
Номер статьи746300
ЖурналFrontiers in Physiology
Том12
DOI
СостояниеОпубликовано - 11 ноя 2021

Предметные области OECD FOS+WOS

  • 3.02 КЛИНИЧЕСКАЯ МЕДИЦИНА
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ
  • 3.01.UM ФИЗИОЛОГИЯ

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