The article studies mathematical simulation of microwave heating of flow in a slotted channel. The internal heat sources, which are proportional to the absorbed microwave energy, obey the Bouguer law. The stationary temperature distributions in the liquid, wall inner surface andmiddle of the wall along the channel have been found from the balance of heat supply and heat release. The maximum temperature values over channel cross sections have also been determined. The heat transfer to the flow was realized in the nonboiling convective regime. The microwave power was selected such that themaximum temperatures and heat fluxes did not exceed themaximumallowable values for the materials.