The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov; Y. V. Seryotkin; N. A. Tumanov; D. Paliwoda; M. Hanfland; A. V. Kurnosov; E. V. Boldyreva

doi:10.1039/c6ra17750f

The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov, E. V. Boldyreva

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

19 Цитирования (Scopus)

Аннотация

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

Язык оригинала	английский
Страницы (с-по)	92629-92637
Число страниц	9
Журнал	RSC Advances
Том	6
Номер выпуска	95
DOI	https://doi.org/10.1039/c6ra17750f
Состояние	Опубликовано - 2016

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10.1039/c6ra17750f

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abstract = "The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.",

author = "Zakharov, {B. A.} and Seryotkin, {Y. V.} and Tumanov, {N. A.} and D. Paliwoda and M. Hanfland and Kurnosov, {A. V.} and Boldyreva, {E. V.}",

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The role of fluids in high-pressure polymorphism of drugs : Different behaviour of β-chlorpropamide in different inert gas and liquid media. / Zakharov, B. A.; Seryotkin, Y. V.; Tumanov, N. A. и др.

В: RSC Advances, Том 6, № 95, 2016, стр. 92629-92637.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Zakharov, B. A.

AU - Seryotkin, Y. V.

AU - Tumanov, N. A.

AU - Paliwoda, D.

AU - Hanfland, M.

AU - Kurnosov, A. V.

AU - Boldyreva, E. V.

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