The limits of normal approximation for adult height

Sergei A. Slavskii, Ivan A. Kuznetsov, Tatiana I. Shashkova, Georgii A. Bazykin, Tatiana I. Axenovich, Fyodor A. Kondrashov, Yurii S. Aulchenko

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Adult height inspired the first biometrical and quantitative genetic studies and is a test-case trait for understanding heritability. The studies of height led to formulation of the classical polygenic model, that has a profound influence on the way we view and analyse complex traits. An essential part of the classical model is an assumption of additivity of effects and normality of the distribution of the residuals. However, it may be expected that the normal approximation will become insufficient in bigger studies. Here, we demonstrate that when the height of hundreds of thousands of individuals is analysed, the model complexity needs to be increased to include non-additive interactions between sex, environment and genes. Alternatively, the use of log-normal approximation allowed us to still use the additive effects model. These findings are important for future genetic and methodologic studies that make use of adult height as an exemplar trait.

Язык оригиналаанглийский
Страницы (с-по)1082-1091
Число страниц10
ЖурналEuropean journal of human genetics
Том29
Номер выпуска7
DOI
СостояниеОпубликовано - июл 2021

Предметные области OECD FOS+WOS

  • 3.02 КЛИНИЧЕСКАЯ МЕДИЦИНА
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ
  • 1.06.CQ БИОХИМИЯ И МОЛЕКУЛЯРНАЯ БИОЛОГИЯ
  • 1.06.KM ГЕНЕТИКА И НАСЛЕДСТВЕННОСТЬ

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