Аннотация
Normally, in human cells, both DNA single- strand breaks (SSBs) and
double-strand breaks (DSBs) arising due to exogenous and endogenous DNA
damaging agents, are efficiently repaired by base excision repair (BER)
and several DSB repair pathways, correspondingly. However, mutations in
genes involved in DNA repair or extensive DNA damage caused by exogenous
or endogenous mutagens may lead to the accumulation of unrepaired DNA
strand breaks (SBs). Accumulation of the persistent SBs results in
genomic instability and may lead to many human diseases including
cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes
and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a
less dramatic effect on the expression of BER genes.
Переведенное название | Взаимодействие между системами репарации NHEJ и BER в NHEJ - дефицитных клетках |
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Язык оригинала | английский |
Страницы | 589 |
Число страниц | 1 |
DOI | |
Состояние | Опубликовано - 2020 |
Событие | Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Российская Федерация Продолжительность: 6 июл. 2020 → 10 июл. 2020 Номер конференции: 12 https://bgrssb.icgbio.ru/2020/ |
Конференция
Конференция | Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) |
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Сокращенный заголовок | BGRS/SB-2020 |
Страна/Tерритория | Российская Федерация |
Город | Новосибирск |
Период | 06.07.2020 → 10.07.2020 |
Адрес в сети Интернет |