The interplay between NHEJ and BER in NHEJ deficient cells

Полина Сергеевна Лощенова; Светлана Владимировна Сергеева; Григорий Леонидович Дианов

doi:10.18699/BGRS/SB-2020-360

The interplay between NHEJ and BER in NHEJ deficient cells

Переведенное название: Взаимодействие между системами репарации NHEJ и BER в NHEJ - дефицитных клетках

Полина Сергеевна Лощенова, Светлана Владимировна Сергеева, Григорий Леонидович Дианов

Лаборатория радиационной биологии (ЛабРБЛ)

Результат исследования: Материалы конференций › тезисы

Аннотация

Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.

Переведенное название	Взаимодействие между системами репарации NHEJ и BER в NHEJ - дефицитных клетках
Язык оригинала	английский
Страницы	589
Число страниц	1
DOI	https://doi.org/10.18699/BGRS/SB-2020-360
Состояние	Опубликовано - 2020
Событие	Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Российская Федерация Продолжительность: 6 июл. 2020 → 10 июл. 2020 Номер конференции: 12 https://bgrssb.icgbio.ru/2020/

Конференция

Конференция	Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Сокращенный заголовок	BGRS/SB-2020
Страна/Tерритория	Российская Федерация
Город	Новосибирск
Период	06.07.2020 → 10.07.2020
Адрес в сети Интернет	https://bgrssb.icgbio.ru/2020/

Доступ к документу

10.18699/BGRS/SB-2020-360

https://www.elibrary.ru/item.asp?id=44042477&pf=1

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Цитировать

Лощенова, П. С., Сергеева, С. В., & Дианов, Г. Л. (2020). The interplay between NHEJ and BER in NHEJ deficient cells. 589. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация. https://doi.org/10.18699/BGRS/SB-2020-360

Лощенова, Полина Сергеевна ; Сергеева, Светлана Владимировна ; Дианов, Григорий Леонидович. / The interplay between NHEJ and BER in NHEJ deficient cells. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация.1 стр.

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title = "The interplay between NHEJ and BER in NHEJ deficient cells",

abstract = "Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.",

keywords = "DNA DAMAGE, BASE EXCISION REPAIR (BER), NON- HOMOLOGOUS END JOINING (NHEJ), TRANSCRIPTION FACTOR SP1",

author = "Лощенова, {Полина Сергеевна} and Сергеева, {Светлана Владимировна} and Дианов, {Григорий Леонидович}",

year = "2020",

doi = "10.18699/BGRS/SB-2020-360",

language = "English",

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note = "null ; Conference date: 06-07-2020 Through 10-07-2020",

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Лощенова, ПС , Сергеева, СВ & Дианов, ГЛ 2020, 'The interplay between NHEJ and BER in NHEJ deficient cells', Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация, 06.07.2020 - 10.07.2020 стр. 589. https://doi.org/10.18699/BGRS/SB-2020-360

The interplay between NHEJ and BER in NHEJ deficient cells. / Лощенова, Полина Сергеевна ; Сергеева, Светлана Владимировна; Дианов, Григорий Леонидович.

2020. 589 Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация.

Результат исследования: Материалы конференций › тезисы

TY - CONF

T1 - The interplay between NHEJ and BER in NHEJ deficient cells

AU - Лощенова, Полина Сергеевна

AU - Сергеева, Светлана Владимировна

AU - Дианов, Григорий Леонидович

N1 - Conference code: 12

PY - 2020

Y1 - 2020

N2 - Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.

AB - Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.

KW - DNA DAMAGE, BASE EXCISION REPAIR (BER), NON- HOMOLOGOUS END JOINING (NHEJ), TRANSCRIPTION FACTOR SP1

U2 - 10.18699/BGRS/SB-2020-360

DO - 10.18699/BGRS/SB-2020-360

M3 - Abstract

SP - 589

Y2 - 6 July 2020 through 10 July 2020

ER -

Лощенова ПС , Сергеева СВ, Дианов ГЛ. The interplay between NHEJ and BER in NHEJ deficient cells. 2020. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация. https://doi.org/10.18699/BGRS/SB-2020-360