The Influence of Proteins on Fate and Biological Role of Circulating DNA

Oleg Tutanov; Svetlana Tamkovich

doi:10.3390/ijms23137224

The Influence of Proteins on Fate and Biological Role of Circulating DNA

Результат исследования: Научные публикации в периодических изданиях › обзорная статья › рецензирование

Аннотация

Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.

Язык оригинала	английский
Номер статьи	7224
Журнал	International Journal of Molecular Sciences
Том	23
Номер выпуска	13
DOI	https://doi.org/10.3390/ijms23137224
Состояние	Опубликовано - 1 июл 2022

Предметные области OECD FOS+WOS

2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
1.04 ХИМИЧЕСКИЕ НАУКИ
1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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title = "The Influence of Proteins on Fate and Biological Role of Circulating DNA",

abstract = "Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA{\textquoteright}s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.",

keywords = "cell surface‐bound DNA, cell‐free tumor DNA, circulating DNA, DNA‐binding proteins, exosomes, extracellular vesicles, Humans, Cell-Free Nucleic Acids/metabolism, Exosomes/metabolism, Neoplasms/genetics",

author = "Oleg Tutanov and Svetlana Tamkovich",

note = "Funding Information: This research was funded by a grant from the Russian Science Foundation, N22‐25‐00130, https://rscf.ru/project/22‐25‐00130/. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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The Influence of Proteins on Fate and Biological Role of Circulating DNA. / Tutanov, Oleg; Tamkovich, Svetlana.

В: International Journal of Molecular Sciences, Том 23, № 13, 7224, 01.07.2022.

Результат исследования: Научные публикации в периодических изданиях › обзорная статья › рецензирование

TY - JOUR

T1 - The Influence of Proteins on Fate and Biological Role of Circulating DNA

AU - Tutanov, Oleg

AU - Tamkovich, Svetlana

N1 - Funding Information: This research was funded by a grant from the Russian Science Foundation, N22‐25‐00130, https://rscf.ru/project/22‐25‐00130/. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.

AB - Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.

KW - cell surface‐bound DNA

KW - cell‐free tumor DNA

KW - circulating DNA

KW - DNA‐binding proteins

KW - exosomes

KW - extracellular vesicles

KW - Humans

KW - Cell-Free Nucleic Acids/metabolism

KW - Exosomes/metabolism

KW - Neoplasms/genetics

UR - http://www.scopus.com/inward/record.url?scp=85133127525&partnerID=8YFLogxK

U2 - 10.3390/ijms23137224

DO - 10.3390/ijms23137224

M3 - Review article

C2 - 35806228

AN - SCOPUS:85133127525

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 13

M1 - 7224

ER -

The Influence of Proteins on Fate and Biological Role of Circulating DNA

Аннотация

Предметные области OECD FOS+WOS

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