The glymphatic system and meningeal lymphatics of the brain: New understanding of brain clearance

Galina Yankova, Olga Bogomyakova, Andrey Tulupov

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование


The glymphatic system and meningeal lymphatics have recently been characterized. Glymphatic system is a glia-dependent system of perivascular channels, and it plays an important role in the removal of interstitial metabolic waste products. The meningeal lymphatics may be a key drainage route for cerebrospinal fluid into the peripheral blood, may contribute to inflammatory reaction and central nervous system (CNS) immune surveillance. Breakdowns and dysfunction of the glymphatic systemand meningeal lymphatics play a crucial role in age-related brain changes, the pathogenesis of neurovascular and neurodegenerative diseases, as well as in brain injuries and tumors. This review discusses the relationship recently characterized meningeal lymphatic vessels with the glymphatic system, which provides perfusion of the CNS with cerebrospinal and interstitial fluids. The review also presents the results of human studies concerning both the presence of meningeal lymphatics and the glymphatic system. A new understanding of how aging, medications, sleep and wake cycles, genetic predisposition, and even body posture affect the brain drainage system has not only changed the idea of brain fluid circulation but has also contributed to an understanding of the pathology and mechanisms of neurodegenerative diseases.

Язык оригиналаанглийский
Страницы (с-по)693-705
Число страниц13
ЖурналReviews in the Neurosciences
Номер выпуска7
Ранняя дата в режиме онлайн22 фев 2021
СостояниеОпубликовано - 1 ноя 2021

Предметные области OECD FOS+WOS



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