Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides

A. A. Fokina; Yu E. Poletaeva; E. A. Burakova; A. Yu Bakulina; T. S. Zatsepin; E. I. Ryabchikova; D. A. Stetsenko

doi:10.1134/S1068162021030067

Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides

A. A. Fokina, Yu E. Poletaeva, E. A. Burakova, A. Yu Bakulina, T. S. Zatsepin, E. I. Ryabchikova, D. A. Stetsenko

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a template and a building block, which incorporates non-nucleotidic linkers, in particular, branching foci connecting two or three oligonucleotide chains. In this work, we have attempted the synthesis of branched oligonucleotide templates for the assembly of a DNA tetrahedron and a DNA cube, a branched oligonucleotide building block (“starlet”), and studied the assembly of a DNA tetrahedron.

Язык оригинала	английский
Страницы (с-по)	700-712
Число страниц	13
Журнал	Russian Journal of Bioorganic Chemistry
Том	47
Номер выпуска	3
DOI	https://doi.org/10.1134/S1068162021030067
Состояние	Опубликовано - мая 2021

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1.06 БИОЛОГИЧЕСКИЕ НАУКИ
1.04 ХИМИЧЕСКИЕ НАУКИ
1.06.CQ БИОХИМИЯ И МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

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title = "Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides",

abstract = "We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a template and a building block, which incorporates non-nucleotidic linkers, in particular, branching foci connecting two or three oligonucleotide chains. In this work, we have attempted the synthesis of branched oligonucleotide templates for the assembly of a DNA tetrahedron and a DNA cube, a branched oligonucleotide building block (“starlet”), and studied the assembly of a DNA tetrahedron.",

keywords = "click chemistry, DNA nanotechnology, nucleic acid, photolabile protecting group, solid-phase synthesis, strain-promoted azide-alkyne cycloaddition (SPAAC)",

author = "Fokina, {A. A.} and Poletaeva, {Yu E.} and Burakova, {E. A.} and Bakulina, {A. Yu} and Zatsepin, {T. S.} and Ryabchikova, {E. I.} and Stetsenko, {D. A.}",

note = "Funding Information: The work was supported by the Russian Foundation for Basic Research (grant nos. 16-03-01055 and 18-29-08062), and the Ministry of Science and Higher Education of the Russian Federation (Novosibirsk State University project FSUS-2020-0035). Publisher Copyright: {\textcopyright} 2021, Pleiades Publishing, Ltd.",

year = "2021",

month = may,

doi = "10.1134/S1068162021030067",

language = "English",

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Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides. / Fokina, A. A.; Poletaeva, Yu E.; Burakova, E. A. и др.

В: Russian Journal of Bioorganic Chemistry, Том 47, № 3, 05.2021, стр. 700-712.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides

AU - Fokina, A. A.

AU - Poletaeva, Yu E.

AU - Burakova, E. A.

AU - Bakulina, A. Yu

AU - Zatsepin, T. S.

AU - Ryabchikova, E. I.

AU - Stetsenko, D. A.

N1 - Funding Information: The work was supported by the Russian Foundation for Basic Research (grant nos. 16-03-01055 and 18-29-08062), and the Ministry of Science and Higher Education of the Russian Federation (Novosibirsk State University project FSUS-2020-0035). Publisher Copyright: © 2021, Pleiades Publishing, Ltd.

PY - 2021/5

Y1 - 2021/5

N2 - We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a template and a building block, which incorporates non-nucleotidic linkers, in particular, branching foci connecting two or three oligonucleotide chains. In this work, we have attempted the synthesis of branched oligonucleotide templates for the assembly of a DNA tetrahedron and a DNA cube, a branched oligonucleotide building block (“starlet”), and studied the assembly of a DNA tetrahedron.

AB - We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a template and a building block, which incorporates non-nucleotidic linkers, in particular, branching foci connecting two or three oligonucleotide chains. In this work, we have attempted the synthesis of branched oligonucleotide templates for the assembly of a DNA tetrahedron and a DNA cube, a branched oligonucleotide building block (“starlet”), and studied the assembly of a DNA tetrahedron.

KW - click chemistry

KW - DNA nanotechnology

KW - nucleic acid

KW - photolabile protecting group

KW - solid-phase synthesis

KW - strain-promoted azide-alkyne cycloaddition (SPAAC)

UR - http://www.scopus.com/inward/record.url?scp=85107623656&partnerID=8YFLogxK

U2 - 10.1134/S1068162021030067

DO - 10.1134/S1068162021030067

M3 - Article

AN - SCOPUS:85107623656

VL - 47

SP - 700

EP - 712

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 3

ER -

Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides

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