Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

D. V. Reshetnikov, S. S. Patrushev, E. E. Shults

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

Язык оригиналаанглийский
Страницы (с-по)855-860
Число страниц6
ЖурналChemistry of Natural Compounds
Том56
Номер выпуска5
DOI
СостояниеОпубликовано - 1 сен 2020

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