Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

D. V. Reshetnikov; S. S. Patrushev; E. E. Shults

doi:10.1007/s10600-020-03169-x

Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

D. V. Reshetnikov, S. S. Patrushev, E. E. Shults

Кафедра органической химии ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

Язык оригинала	английский
Страницы (с-по)	855-860
Число страниц	6
Журнал	Chemistry of Natural Compounds
Том	56
Номер выпуска	5
DOI	https://doi.org/10.1007/s10600-020-03169-x
Состояние	Опубликовано - 1 сен 2020

Предметные области OECD FOS+WOS

3.01.TU ФАРМАКОЛОГИЯ И ФАРМАЦИЯ

Доступ к документу

10.1007/s10600-020-03169-x

Link to publication in Scopus

Fingerprint

Подробные сведения о темах исследования «Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

@article{676180d188f145a7bf33629239054666,

title = "Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers",

abstract = "8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.",

keywords = "caffeine, eudesmanolides, methylenelactones, Michael reaction",

author = "Reshetnikov, {D. V.} and Patrushev, {S. S.} and Shults, {E. E.}",

year = "2020",

month = sep,

day = "1",

doi = "10.1007/s10600-020-03169-x",

language = "English",

volume = "56",

pages = "855--860",

journal = "Chemistry of Natural Compounds",

issn = "0009-3130",

publisher = "Springer New York",

number = "5",

}

Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers. / Reshetnikov, D. V.; Patrushev, S. S.; Shults, E. E.

В: Chemistry of Natural Compounds, Том 56, № 5, 01.09.2020, стр. 855-860.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

AU - Reshetnikov, D. V.

AU - Patrushev, S. S.

AU - Shults, E. E.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - 8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

AB - 8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

KW - caffeine

KW - eudesmanolides

KW - methylenelactones

KW - Michael reaction

UR - http://www.scopus.com/inward/record.url?scp=85090943791&partnerID=8YFLogxK

U2 - 10.1007/s10600-020-03169-x

DO - 10.1007/s10600-020-03169-x

M3 - Article

AN - SCOPUS:85090943791

VL - 56

SP - 855

EP - 860

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 5

ER -