Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

Yu V. Kharitonov; M. M. Shakirov; M. A. Pokrovskii; A. G. Pokrovskii; E. E. Shul’Ts

doi:10.1007/s10600-017-1915-5

Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

Yu V. Kharitonov, M. M. Shakirov, M. A. Pokrovskii, A. G. Pokrovskii, E. E. Shul’Ts

Кафедра фундаментальной медицины ИМП

Результат исследования: Научные публикации в периодических изданиях › статья

5 Цитирования (Scopus)

Аннотация

(17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.

Язык оригинала	английский
Страницы (с-по)	77-82
Число страниц	6
Журнал	Chemistry of Natural Compounds
Том	53
Номер выпуска	1
DOI	https://doi.org/10.1007/s10600-017-1915-5
Состояние	Опубликовано - 1 янв 2017

Доступ к документу

10.1007/s10600-017-1915-5

Link to publication in Scopus

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Цитировать

Kharitonov, Y. V., Shakirov, M. M., Pokrovskii, M. A., Pokrovskii, A. G., & Shul’Ts, E. E. (2017). Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid. Chemistry of Natural Compounds, 53(1), 77-82. https://doi.org/10.1007/s10600-017-1915-5

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abstract = "(17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.",

keywords = "1,2,3-triazoles, Cytotoxicity, Dialkynyllabdadienes, Lambertianic acid, Macroheterocycles",

author = "Kharitonov, {Yu V.} and Shakirov, {M. M.} and Pokrovskii, {M. A.} and Pokrovskii, {A. G.} and Shul{\textquoteright}Ts, {E. E.}",

year = "2017",

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Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid. / Kharitonov, Yu V.; Shakirov, M. M.; Pokrovskii, M. A.; Pokrovskii, A. G.; Shul’Ts, E. E.

В: Chemistry of Natural Compounds, Том 53, № 1, 01.01.2017, стр. 77-82.

Результат исследования: Научные публикации в периодических изданиях › статья

TY - JOUR

T1 - Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

AU - Kharitonov, Yu V.

AU - Shakirov, M. M.

AU - Pokrovskii, M. A.

AU - Pokrovskii, A. G.

AU - Shul’Ts, E. E.

PY - 2017/1/1

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N2 - (17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.

AB - (17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.

KW - 1,2,3-triazoles

KW - Cytotoxicity

KW - Dialkynyllabdadienes

KW - Lambertianic acid

KW - Macroheterocycles

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U2 - 10.1007/s10600-017-1915-5

DO - 10.1007/s10600-017-1915-5

M3 - Article

AN - SCOPUS:85013421857

VL - 53

SP - 77

EP - 82

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

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IS - 1

ER -