Synthetic Approaches for 15N-Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields

Nikita V. Chukanov, Roman V. Shchepin, Sameer M. Joshi, Mohammad S.H. Kabir, Oleg G. Salnikov, Alexandra Svyatova, Igor V. Koptyug, Juri G. Gelovani, Eduard Y. Chekmenev

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

1 Цитирования (Scopus)


NMR hyperpolarization techniques enhance nuclear spin polarization by several orders of magnitude resulting in corresponding sensitivity gains. This enormous sensitivity gain enables new applications ranging from studies of small molecules by using high-resolution NMR spectroscopy to real-time metabolic imaging in vivo. Several hyperpolarization techniques exist for hyperpolarization of a large repertoire of nuclear spins, although the 13C and 15N sites of biocompatible agents are the key targets due to their widespread use in biochemical pathways. Moreover, their long T1 allows hyperpolarized states to be retained for up to tens of minutes. Signal amplification by reversible exchange (SABRE) is a low-cost and ultrafast hyperpolarization technique that has been shown to be versatile for the hyperpolarization of 15N nuclei. Although large sensitivity gains are enabled by hyperpolarization, 15N natural abundance is only ∼0.4 %, so isotopic labeling of the molecules to be hyperpolarized is required in order to take full advantage of the hyperpolarized state. Herein, we describe selected advances in the preparation of 15N-labeled compounds with the primary emphasis on using these compounds for SABRE polarization in microtesla magnetic fields through spontaneous polarization transfer from parahydrogen. Also, these principles can certainly be applied for hyperpolarization of these emerging contrast agents using dynamic nuclear polarization and other techniques.

Язык оригиналаанглийский
ЖурналChemistry - A European Journal
Ранняя дата в режиме онлайн15 апр 2021
СостояниеЭлектронная публикация перед печатью - 15 апр 2021

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