Synthesis, structure and study of the biological activity of Co(II), Ni(II), and Cu(II) complexes with an enaminedione derivative

Yu A. Eremina, E. A. Ermakova, T. S. Sukhikh, L. S. Klyushova, I. V. El’tsov, D. G. Samsonenko, V. V. Dotsenko, A. A. Zubenko, L. N. Fetisov, K. N. Kononenko, E. V. Lider

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

[Cu(L)2] (1), [Co(L)2] (2), [Ni(L)2]·H2O (3) complexes where L is 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dionate are synthesized. Single crystals of complexes 1-3 are obtained. According to X-ray crystallographic data, in the Co and Ni complexes, a coordination polyhedron N2O4 is a distorted octahedron, and in the Cu complex, N2O2 is a distorted square. L is a tridentate ligand coordinated by oxygen atoms of carbonyl and methoxy groups as well as the nitrogen atom of the amide group. The cytotoxic properties of 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dione and respective complexes are studied on the Hep2 cell line (human laryngeal carcinoma). The compounds are shown to not exhibit cytotoxic properties in the studied concentration range (1-50 μM). Antibacterial, protistocidal, and fungistatic properties of HL, its structural analogue 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL1), and complexes on their base are also studied. The antibacterial activity of HL and [Co(L1)2(C2H5OH)2] against S. aureus, of HL1 and [Co(L)2] against E. coli is revealed within 25-30% of the activity of reference drugs (ciprofloxacin, furazolidone). The [Ni(L1)2(C2H5OH)2] complex is found to have a pronounced protistocidal activity. Furthermore, the behavior of the [Ni(L)2]·H2O complex in phosphate buffered saline is analyzed at storage times t = 0 h, 24 h, 48 h and also in an aqueous solution at different pH values.

Язык оригиналаанглийский
Страницы (с-по)309-320
Число страниц12
ЖурналJournal of Structural Chemistry
Том62
Номер выпуска2
DOI
СостояниеОпубликовано - фев 2021

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ
  • 1.04.EC ХИМИЯ, НЕОРГАНИЧЕСКАЯ И ЯДЕРНАЯ
  • 1.04.EI ХИМИЯ, ФИЗИЧЕСКАЯ

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