Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (−)-camphor thiosemicarbazone

Tatyana E. Kokina, Ludmila A. Glinskaya, Liliya A. Sheludyakova, Yuliya A. Eremina, Lubov S. Klyushova, Vladislav Yu Komarov, Dmitriy A. Piryazev, Alexey V. Tkachev, Stanislav V. Larionov

Результат исследования: Научные публикации в периодических изданияхстатья

3 Цитирования (Scopus)

Аннотация

Complexes [Zn(L2 )2Cl2 ], [Pd2(L2)2Cl4], and CuL2Cl, where L2 is (−)-camphor thiosemicarbazone, were synthesized. The structures of complexes [Zn(L2)2Cl2] and [Pd2(L2)2Cl4] were determined by X-ray diffraction. The crystal structure of complex [Zn(L2)2Cl2] contains mononuclear molecules with distorted tetrahedral {ZnCl2S2} coordination units and monodentate L2 ligands. Complex [Pd2(L2)2Cl4] has binuclear structure with Pd metal centers linked by L2 ligands via μ2-S atoms. Complex CuL2Cl, according to IR and NMR spectra contains S and Cl atoms in the coordination sphere of ion Cu+ . Complexes [Pd(tsc)Cl2] and Zn(tsc)2Cl2 (where tsc is thiosemicarbazide) were also obtained to determine the influence of the terpene moiety on cytotoxic properties of these compounds. Mononuclear complex [Pd(tsc)Cl2] contains an NSCl2 planar square coordination polyhedron, and tsc is a bidentate chelate ligand. The effects of tsc, L2 , and the complexes with tsc and L2 on viability of the MCF-7 cell line were investigated next. The results showed that tsc and L2 are nontoxic at the tested concentrations (1–50 μM). All the complexes exerted a significant dose-dependent cytotoxic effect, whereas complex CuL2 Cl was found to have the lowest half-maximal inhibitory concentration (IC50)

Язык оригиналаанглийский
Страницы (с-по)121-130
Число страниц10
ЖурналPolyhedron
Том163
DOI
СостояниеОпубликовано - 1 мая 2019

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