TY - JOUR
T1 - Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (−)-camphor thiosemicarbazone
AU - Kokina, Tatyana E.
AU - Glinskaya, Ludmila A.
AU - Sheludyakova, Liliya A.
AU - Eremina, Yuliya A.
AU - Klyushova, Lubov S.
AU - Komarov, Vladislav Yu
AU - Piryazev, Dmitriy A.
AU - Tkachev, Alexey V.
AU - Larionov, Stanislav V.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Complexes [Zn(L2 )2Cl2 ], [Pd2(L2)2Cl4], and CuL2Cl, where L2 is (−)-camphor thiosemicarbazone, were synthesized. The structures of complexes [Zn(L2)2Cl2] and [Pd2(L2)2Cl4] were determined by X-ray diffraction. The crystal structure of complex [Zn(L2)2Cl2] contains mononuclear molecules with distorted tetrahedral {ZnCl2S2} coordination units and monodentate L2 ligands. Complex [Pd2(L2)2Cl4] has binuclear structure with Pd metal centers linked by L2 ligands via μ2-S atoms. Complex CuL2Cl, according to IR and NMR spectra contains S and Cl atoms in the coordination sphere of ion Cu+ . Complexes [Pd(tsc)Cl2] and Zn(tsc)2Cl2 (where tsc is thiosemicarbazide) were also obtained to determine the influence of the terpene moiety on cytotoxic properties of these compounds. Mononuclear complex [Pd(tsc)Cl2] contains an NSCl2 planar square coordination polyhedron, and tsc is a bidentate chelate ligand. The effects of tsc, L2 , and the complexes with tsc and L2 on viability of the MCF-7 cell line were investigated next. The results showed that tsc and L2 are nontoxic at the tested concentrations (1–50 μM). All the complexes exerted a significant dose-dependent cytotoxic effect, whereas complex CuL2 Cl was found to have the lowest half-maximal inhibitory concentration (IC50)
AB - Complexes [Zn(L2 )2Cl2 ], [Pd2(L2)2Cl4], and CuL2Cl, where L2 is (−)-camphor thiosemicarbazone, were synthesized. The structures of complexes [Zn(L2)2Cl2] and [Pd2(L2)2Cl4] were determined by X-ray diffraction. The crystal structure of complex [Zn(L2)2Cl2] contains mononuclear molecules with distorted tetrahedral {ZnCl2S2} coordination units and monodentate L2 ligands. Complex [Pd2(L2)2Cl4] has binuclear structure with Pd metal centers linked by L2 ligands via μ2-S atoms. Complex CuL2Cl, according to IR and NMR spectra contains S and Cl atoms in the coordination sphere of ion Cu+ . Complexes [Pd(tsc)Cl2] and Zn(tsc)2Cl2 (where tsc is thiosemicarbazide) were also obtained to determine the influence of the terpene moiety on cytotoxic properties of these compounds. Mononuclear complex [Pd(tsc)Cl2] contains an NSCl2 planar square coordination polyhedron, and tsc is a bidentate chelate ligand. The effects of tsc, L2 , and the complexes with tsc and L2 on viability of the MCF-7 cell line were investigated next. The results showed that tsc and L2 are nontoxic at the tested concentrations (1–50 μM). All the complexes exerted a significant dose-dependent cytotoxic effect, whereas complex CuL2 Cl was found to have the lowest half-maximal inhibitory concentration (IC50)
KW - Complexes
KW - Crystal structure
KW - Cytotoxicity
KW - Terpene
KW - Thiosemicarbazone
KW - ESI-MASS
KW - ANTIPROLIFERATIVE ACTIVITY
KW - TRANSITION-METAL-COMPLEXES
KW - CRYSTAL-STRUCTURE
KW - (+)-CAMPHOR
KW - COORDINATION
KW - SPECTROSCOPY
KW - DNA/PROTEIN
KW - DERIVATIVES
KW - ANTIMICROBIAL ACTIVITY
UR - http://www.scopus.com/inward/record.url?scp=85062286234&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2019.02.020
DO - 10.1016/j.poly.2019.02.020
M3 - Article
AN - SCOPUS:85062286234
VL - 163
SP - 121
EP - 130
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
ER -