@article{3010c66a950248b79527395c6643968c,
title = "Synthesis of polyfluorinated o-hydroxyacetophenones – convenient precursors of 3-benzylidene-2-phenylchroman-4-ones",
abstract = "A simple and efficient approach to the synthesis of fluorinated o-hydroxyacetophenones in good to excellent yields is reported. We demonstrated a convenient method for replacing the iodine atom in o-iodophenols with MeC(O)-group through the introduction and subsequent hydrolysis of TIPS-CC-moiety by of p-toluenesulfonic acid monohydrate. The resulting compounds may serve as precursors for the synthesis of polyfluorinated 3-benzylidene-2-phenylchroman-4-one derivatives that are of interest as objects for the evaluation of their pharmacological properties.",
keywords = "Aldol reaction, Fluorinated o-iodophenols, Hydration reaction, o-hydroxyacetophenones, Palladium catalysis, Sonogashira coupling, NAPHTHOLS, ACID, DISCOVERY, SOLVENT, PHENOLS, DIRECT ORTHO-ACYLATION, FLUORINE, INHIBITORS",
author = "Larisa Politanskaya and Evgeny Tretyakov and Chanjuan Xi",
note = "The authors thank the Russian Foundation for Basic Research (grant No 19-53-53003) and NSFC (grant No 21911530097) for financial support and the Chemical Service Center SB RAS for spectral and analytical measurements. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2020",
month = jan,
doi = "10.1016/j.jfluchem.2019.109435",
language = "English",
volume = "229",
journal = "Journal of Fluorine Chemistry",
issn = "0022-1139",
publisher = "Elsevier",
}