Аннотация
A simple and efficient approach to the synthesis of fluorinated o-hydroxyacetophenones in good to excellent yields is reported. We demonstrated a convenient method for replacing the iodine atom in o-iodophenols with MeC(O)-group through the introduction and subsequent hydrolysis of TIPS-CC-moiety by of p-toluenesulfonic acid monohydrate. The resulting compounds may serve as precursors for the synthesis of polyfluorinated 3-benzylidene-2-phenylchroman-4-one derivatives that are of interest as objects for the evaluation of their pharmacological properties.
Язык оригинала | английский |
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Номер статьи | 109435 |
Число страниц | 8 |
Журнал | Journal of Fluorine Chemistry |
Том | 229 |
DOI | |
Состояние | Опубликовано - янв 2020 |