Synthesis of polyfluorinated aminoquinolines via nitroquinolines

Alexandrina D. Skolyapova, Galina A. Selivanova, Evgeny V. Tretyakov, Irina Yu Bagryanskaya, Vitalij D. Shteingarts

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)


Transformation of 14 quinolines polyfluorinated in the benzene moiety was investigated in nitration systems: a mixture of HNO3 and H2SO4, NaNO3 in H2SO4, NO2BF3OH in sulfolane, or NaNO3 in oleum. 5-Nitro- and/or 8-nitro derivatives formed if positions 5 or 8 were unoccupied in the starting compounds. Otherwise, nitro products were not detectable, and the initial compounds were oxidized. In some cases, F atoms at the ortho position relative to the nitro group were substituted thus affording hydroxynitroquinolines. Polyfluorinated 2-chloroquinolines were nitrated more easily than were quinolines not containing a substituent at position 2. Thus, a method is proposed for reduction of nitroquinolines to aminoquinolines that are not available via other approaches.

Язык оригиналаанглийский
Страницы (с-по)14-23
Число страниц10
ЖурналJournal of Fluorine Chemistry
СостояниеОпубликовано - 1 июл. 2018


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