Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09

George V. Teplov; Evgeny V. Suslov; Vladimir V. Zarubaev; Anna A. Shtro; Liubov A. Karpinskaya; Artem D. Rogachev; Dina V. Korchagina; Konstantin P. Volcho; Nariman F. Salakhutdinov; Oleg I. Kiselev

doi:10.2174/1570180811310060002

Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09

George V. Teplov, Evgeny V. Suslov, Vladimir V. Zarubaev, Anna A. Shtro, Liubov A. Karpinskaya, Artem D. Rogachev, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Oleg I. Kiselev

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

20 Цитирования (Scopus)

Аннотация

A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

Язык оригинала	английский
Страницы (с-по)	477-485
Число страниц	9
Журнал	Letters in Drug Design and Discovery
Том	10
Номер выпуска	6
DOI	https://doi.org/10.2174/1570180811310060002
Состояние	Опубликовано - июл 2013
Опубликовано для внешнего пользования	Да

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10.2174/1570180811310060002

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Teplov, G. V., Suslov, E. V., Zarubaev, V. V., Shtro, A. A., Karpinskaya, L. A., Rogachev, A. D., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., & Kiselev, O. I. (2013). Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09. Letters in Drug Design and Discovery, 10(6), 477-485. https://doi.org/10.2174/1570180811310060002

Teplov, George V. ; Suslov, Evgeny V. ; Zarubaev, Vladimir V. ; Shtro, Anna A. ; Karpinskaya, Liubov A. ; Rogachev, Artem D. ; Korchagina, Dina V. ; Volcho, Konstantin P. ; Salakhutdinov, Nariman F. ; Kiselev, Oleg I. / Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09. В: Letters in Drug Design and Discovery. 2013 ; Том 10, № 6. стр. 477-485.

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title = "Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09",

abstract = "A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.",

keywords = "(H1N1)pdm09, Adamantyamine, Antiviral, Influenza, Monoterpenoid, Resistance",

author = "Teplov, {George V.} and Suslov, {Evgeny V.} and Zarubaev, {Vladimir V.} and Shtro, {Anna A.} and Karpinskaya, {Liubov A.} and Rogachev, {Artem D.} and Korchagina, {Dina V.} and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.} and Kiselev, {Oleg I.}",

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doi = "10.2174/1570180811310060002",

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Teplov, GV, Suslov, EV, Zarubaev, VV, Shtro, AA, Karpinskaya, LA, Rogachev, AD, Korchagina, DV, Volcho, KP, Salakhutdinov, NF & Kiselev, OI 2013, 'Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09', Letters in Drug Design and Discovery, том. 10, № 6, стр. 477-485. https://doi.org/10.2174/1570180811310060002

Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09. / Teplov, George V.; Suslov, Evgeny V.; Zarubaev, Vladimir V.; Shtro, Anna A.; Karpinskaya, Liubov A.; Rogachev, Artem D.; Korchagina, Dina V.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Kiselev, Oleg I.

В: Letters in Drug Design and Discovery, Том 10, № 6, 07.2013, стр. 477-485.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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T1 - Synthesis of new compounds combining adamantanamine and monoterpene fragments and their antiviral activity against influenza virus A(H1N1)pdm09

AU - Teplov, George V.

AU - Suslov, Evgeny V.

AU - Zarubaev, Vladimir V.

AU - Shtro, Anna A.

AU - Karpinskaya, Liubov A.

AU - Rogachev, Artem D.

AU - Korchagina, Dina V.

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

AU - Kiselev, Oleg I.

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AB - A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.

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