Аннотация
A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.
Язык оригинала | английский |
---|---|
Страницы (с-по) | 477-485 |
Число страниц | 9 |
Журнал | Letters in Drug Design and Discovery |
Том | 10 |
Номер выпуска | 6 |
DOI | |
Состояние | Опубликовано - июл 2013 |
Опубликовано для внешнего пользования | Да |