Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments

Kirill P. Cheremnykh, Viktor Savel’ev, Oleg P. Shkurko, Elvira E. Shults

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    1 Цитирования (Scopus)

    Аннотация

    [Figure not available: see fulltext.] The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.

    Язык оригиналаанглийский
    Страницы (с-по)1131-1138
    Число страниц8
    ЖурналChemistry of Heterocyclic Compounds
    Том54
    Номер выпуска12
    DOI
    СостояниеОпубликовано - 18 янв 2019

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