Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance

E. V. Timakova; E. I. Bun’kova; L. I. Afonina; Yu M. Yukhin; V. A. Volodin

doi:10.1134/S1070427221070077

Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance

Переведенное название: Синтез фармацевтической субстанции основного сукцината висмута(III) высокой частоты

E. V. Timakova, E. I. Bun’kova, L. I. Afonina, Yu M. Yukhin, V. A. Volodin

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

Для получения фармацевтической субстанции основного сукцината висмута состава С2Н4(СООBiO)2, отвечающего требованиям высокой чистоты по содержанию примесных металлов, исследованы процессы взаимодействия твердого тригидрата пентанитрата тригидроксо-пентаоксо-гексависмута(III) состава [Bi6O5(OH)3](NO3)5·3H2O и моноклинной модификации оксида висмута α-Bi2O3 с раствором янтарной кислоты. Предложен способ получения основного сукцината висмута(III), включающий стадии гидролитической переработки технологического азотнокислого раствора висмута с получением высокочистого соединения состава [Bi6O5(OH)3](NO3)5·3H2O, его обработки раствором NaOH с получением мелкокристаллического α-Bi2O3 и последующего взаимодействия оксида висмута с раствором янтарной кислоты. Состав субстанции подтвержден методами рентгенофазового и химического анализа, ИК- и КР-спектроскопии, термогравиметрии; определено содержание примесных металлов атомно-абсорбционным методом.

Переведенное название	Синтез фармацевтической субстанции основного сукцината висмута(III) высокой частоты
Язык оригинала	английский
Страницы (с-по)	911-919
Число страниц	9
Журнал	Russian Journal of Applied Chemistry
Том	94
Номер выпуска	7
DOI	https://doi.org/10.1134/S1070427221070077
Состояние	Опубликовано - июл. 2021

Предметные области OECD FOS+WOS

2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
1.04 ХИМИЧЕСКИЕ НАУКИ

ГРНТИ

31 ХИМИЯ

Доступ к документу

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@article{5b280aebfcc64ecaa57c3028cbd3e9e1,

title = "Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance",

abstract = "Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.",

keywords = "basic bismuth(III) succinate, bismuth(III) oxide, bismuth(III) oxonitrate, impurity metals, pharmaceutical substance, preparation procedure, succinic acid",

author = "Timakova, {E. V.} and Bun{\textquoteright}kova, {E. I.} and Afonina, {L. I.} and Yukhin, {Yu M.} and Volodin, {V. A.}",

note = "Funding Information: The authors are grateful to the Center for Shared Use High Technologies and Nanosystems Analytics at the Novosibirsk State University for the opportunity to use the equipment for recording the Raman spectra. Publisher Copyright: {\textcopyright} 2021, Pleiades Publishing, Ltd.",

year = "2021",

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doi = "10.1134/S1070427221070077",

language = "English",

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Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance. / Timakova, E. V.; Bun’kova, E. I.; Afonina, L. I. и др.

В: Russian Journal of Applied Chemistry, Том 94, № 7, 07.2021, стр. 911-919.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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T1 - Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance

AU - Timakova, E. V.

AU - Bun’kova, E. I.

AU - Afonina, L. I.

AU - Yukhin, Yu M.

AU - Volodin, V. A.

N1 - Funding Information: The authors are grateful to the Center for Shared Use High Technologies and Nanosystems Analytics at the Novosibirsk State University for the opportunity to use the equipment for recording the Raman spectra. Publisher Copyright: © 2021, Pleiades Publishing, Ltd.

PY - 2021/7

Y1 - 2021/7

N2 - Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.

AB - Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.

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