Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity

Kseniya S. Kovaleva; Fedor I. Zubkov; Nikolay I. Bormotov; Roman A. Novikov; Pavel V. Dorovatovskii; Victor N. Khrustalev; Yuriy V. Gatilov; Vladimir V. Zarubaev; Olga I. Yarovaya; Larisa N. Shishkina; Nariman F. Salakhutdinov

doi:10.1039/c8md00442k

Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity

Kseniya S. Kovaleva, Fedor I. Zubkov, Nikolay I. Bormotov, Roman A. Novikov, Pavel V. Dorovatovskii, Victor N. Khrustalev, Yuriy V. Gatilov, Vladimir V. Zarubaev, Olga I. Yarovaya, Larisa N. Shishkina, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданиях › статья

2 Цитирования (Scopus)

Аннотация

The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.

Язык оригинала	английский
Страницы (с-по)	2072-2082
Число страниц	11
Журнал	MedChemComm
Том	9
Номер выпуска	12
DOI	https://doi.org/10.1039/c8md00442k
Состояние	Опубликовано - 1 дек 2018

Доступ к документу

10.1039/c8md00442k

Link to publication in Scopus

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Цитировать

Kovaleva, K. S., Zubkov, F. I., Bormotov, N. I., Novikov, R. A., Dorovatovskii, P. V., Khrustalev, V. N., Gatilov, Y. V., Zarubaev, V. V., Yarovaya, O. I., Shishkina, L. N., & Salakhutdinov, N. F. (2018). Synthesis of d-(+)-camphor-based: N -acylhydrazones and their antiviral activity. MedChemComm, 9(12), 2072-2082. https://doi.org/10.1039/c8md00442k

Kovaleva, Kseniya S. ; Zubkov, Fedor I. ; Bormotov, Nikolay I. ; Novikov, Roman A. ; Dorovatovskii, Pavel V. ; Khrustalev, Victor N. ; Gatilov, Yuriy V. ; Zarubaev, Vladimir V. ; Yarovaya, Olga I. ; Shishkina, Larisa N. ; Salakhutdinov, Nariman F. / Synthesis of d-(+)-camphor-based : N -acylhydrazones and their antiviral activity. В: MedChemComm. 2018 ; Том 9, № 12. стр. 2072-2082.

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abstract = "The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.",

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Synthesis of d-(+)-camphor-based : N -acylhydrazones and their antiviral activity. / Kovaleva, Kseniya S.; Zubkov, Fedor I.; Bormotov, Nikolay I.; Novikov, Roman A.; Dorovatovskii, Pavel V.; Khrustalev, Victor N.; Gatilov, Yuriy V.; Zarubaev, Vladimir V.; Yarovaya, Olga I.; Shishkina, Larisa N.; Salakhutdinov, Nariman F.

В: MedChemComm, Том 9, № 12, 01.12.2018, стр. 2072-2082.

Результат исследования: Научные публикации в периодических изданиях › статья

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AU - Zubkov, Fedor I.

AU - Bormotov, Nikolay I.

AU - Novikov, Roman A.

AU - Dorovatovskii, Pavel V.

AU - Khrustalev, Victor N.

AU - Gatilov, Yuriy V.

AU - Zarubaev, Vladimir V.

AU - Yarovaya, Olga I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

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