Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats

V. S. Tyukova, S. A. Kedik, A. V. Panov, E. S. Zhavoronok, D. I. Mendeleev, I. N. Senchikhin, A. Zh Fursova, Yu V. Rumyantseva, N. G. Kolosova

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.

Язык оригиналаанглийский
Страницы (с-по)1158-1163
Число страниц6
ЖурналPharmaceutical Chemistry Journal
Том53
Номер выпуска12
DOI
СостояниеОпубликовано - 1 мар 2020

    Fingerprint

Цитировать

Tyukova, V. S., Kedik, S. A., Panov, A. V., Zhavoronok, E. S., Mendeleev, D. I., Senchikhin, I. N., Fursova, A. Z., Rumyantseva, Y. V., & Kolosova, N. G. (2020). Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. Pharmaceutical Chemistry Journal, 53(12), 1158-1163. https://doi.org/10.1007/s11094-020-02140-y