Аннотация
A simple method for the synthesis of sterically shielded pyrrolidine nitroxides, including the title compound, has been suggested. The key procedure implies assembling the pyrrolidine ring from α-amino acid, ketone, and activated alkene in a three-component domino process, followed by oxidation to nitrone and Grignard reagent addition. The new nitroxides demonstrate very high stability against reduction with ascorbate.
Язык оригинала | английский |
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Страницы (с-по) | 5392-5397 |
Число страниц | 6 |
Журнал | Journal of Organic Chemistry |
Том | 83 |
Номер выпуска | 10 |
DOI | |
Состояние | Опубликовано - 18 мая 2018 |