Аннотация
N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.
Язык оригинала | английский |
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Страницы (с-по) | 1041-1046 |
Число страниц | 6 |
Журнал | Russian Chemical Bulletin |
Том | 68 |
Номер выпуска | 5 |
DOI | |
Состояние | Опубликовано - 1 мая 2019 |