Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

A. S. Sokolova, D. V. Baranova, O. I. Yarovaya, D. S. Baev, O. A. Polezhaeva, A. V. Zybkina, D. N. Shcherbakov, T. G. Tolstikova, N. F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Язык оригиналаанглийский
Страницы (с-по)1041-1046
Число страниц6
ЖурналRussian Chemical Bulletin
Том68
Номер выпуска5
DOI
СостояниеОпубликовано - 1 мая 2019

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