Аннотация
The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9-O-(heptafluoro-4’-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 μg mL−1, tetrahydroberberrubine 9-O-pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3±3.5%.
Язык оригинала | английский |
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Страницы (с-по) | 1052-1060 |
Число страниц | 9 |
Журнал | Russian Chemical Bulletin |
Том | 68 |
Номер выпуска | 5 |
DOI | |
Состояние | Опубликовано - 1 мая 2019 |