1 Цитирования (Scopus)

Аннотация

The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9-O-(heptafluoro-4’-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 μg mL−1, tetrahydroberberrubine 9-O-pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3±3.5%.

Язык оригиналаанглийский
Страницы (с-по)1052-1060
Число страниц9
ЖурналRussian Chemical Bulletin
Том68
Номер выпуска5
DOI
СостояниеОпубликовано - 1 мая 2019

Fingerprint Подробные сведения о темах исследования «Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates». Вместе они формируют уникальный семантический отпечаток (fingerprint).

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