Synthesis and 15N NMR Signal Amplification by Reversible Exchange of [15N]Dalfampridine at Microtesla Magnetic Fields

Nikita V. Chukanov, Oleg G. Salnikov, Ivan A. Trofimov, Mohammad S.H. Kabir, Kirill V. Kovtunov, Igor V. Koptyug, Eduard Y. Chekmenev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

Signal Amplification by Reversible Exchange (SABRE) technique enables nuclear spin hyperpolarization of wide range of compounds using parahydrogen. Here we present the synthetic approach to prepare 15N-labeled [15N]dalfampridine (4-amino[15N]pyridine) utilized as a drug to reduce the symptoms of multiple sclerosis. The synthesized compound was hyperpolarized using SABRE at microtesla magnetic fields (SABRE-SHEATH technique) with up to 2.0 % 15N polarization. The 7-hour-long activation of SABRE pre-catalyst [Ir(IMes)(COD)Cl] in the presence of [15N]dalfampridine can be remedied by the use of pyridine co-ligand for catalyst activation while retaining the 15N polarization levels of [15N]dalfampridine. The effects of experimental conditions such as polarization transfer magnetic field, temperature, concentration, parahydrogen flow rate and pressure on 15N polarization levels of free and equatorial catalyst-bound [15N]dalfampridine were investigated. Moreover, we studied 15N polarization build-up and decay at magnetic field of less than 0.04 μT as well as 15N polarization decay at the Earth's magnetic field and at 1.4 T.

Язык оригиналаанглийский
Страницы (с-по)960-967
Число страниц8
ЖурналChemPhysChem
Том22
Номер выпуска10
Ранняя дата в режиме онлайн18 мар 2021
DOI
СостояниеОпубликовано - 17 мая 2021

Предметные области OECD FOS+WOS

  • 1.03 ФИЗИЧЕСКИЕ НАУКИ И АСТРОНОМИЯ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ

Fingerprint Подробные сведения о темах исследования «Synthesis and <sup>15</sup>N NMR Signal Amplification by Reversible Exchange of [<sup>15</sup>N]Dalfampridine at Microtesla Magnetic Fields». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать