Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

A. L. Zakharenko; E. S. Mozhaitsev; E. V. Suslov; D. V. Korchagina; K. P. Volcho; N. F. Salakhutdinov; O. I. Lavrik

doi:10.1007/s10600-018-2443-7

Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

A. L. Zakharenko, E. S. Mozhaitsev, E. V. Suslov, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov, O. I. Lavrik

Результат исследования: Научные публикации в периодических изданиях › статья

3 Цитирования (Scopus)

Аннотация

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC₅₀ = 5.5–7.1 μM.

Язык оригинала	английский
Страницы (с-по)	672-676
Число страниц	5
Журнал	Chemistry of Natural Compounds
Том	54
Номер выпуска	4
DOI	https://doi.org/10.1007/s10600-018-2443-7
Состояние	Опубликовано - 1 июл 2018

Доступ к документу

10.1007/s10600-018-2443-7

Link to publication in Scopus

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Цитировать

Zakharenko, A. L., Mozhaitsev, E. S., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., & Lavrik, O. I. (2018). Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). Chemistry of Natural Compounds, 54(4), 672-676. https://doi.org/10.1007/s10600-018-2443-7

Zakharenko, A. L. ; Mozhaitsev, E. S. ; Suslov, E. V. ; Korchagina, D. V. ; Volcho, K. P. ; Salakhutdinov, N. F. ; Lavrik, O. I. / Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). В: Chemistry of Natural Compounds. 2018 ; Том 54, № 4. стр. 672-676.

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abstract = "Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.",

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Zakharenko, AL, Mozhaitsev, ES, Suslov, EV, Korchagina, DV, Volcho, KP, Salakhutdinov, NF & Lavrik, OI 2018, 'Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)', Chemistry of Natural Compounds, том. 54, № 4, стр. 672-676. https://doi.org/10.1007/s10600-018-2443-7

Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). / Zakharenko, A. L.; Mozhaitsev, E. S.; Suslov, E. V.; Korchagina, D. V.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.

В: Chemistry of Natural Compounds, Том 54, № 4, 01.07.2018, стр. 672-676.

Результат исследования: Научные публикации в периодических изданиях › статья

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AU - Zakharenko, A. L.

AU - Mozhaitsev, E. S.

AU - Suslov, E. V.

AU - Korchagina, D. V.

AU - Volcho, K. P.

AU - Salakhutdinov, N. F.

AU - Lavrik, O. I.

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AB - Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.

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KW - DNA repair inhibitor

KW - monoterpene

KW - Schiff base

KW - tyrosyl-DNA phosphodiesterase 1

KW - TARGET

KW - CAMPTOTHECIN

KW - BIOLOGICAL EVALUATION

KW - TOP1

KW - IDENTIFICATION

KW - MOIETIES

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