@article{fa17bc35d02f47fa922299426a263322,
title = "Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)",
abstract = "Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.",
keywords = "adamantane, DNA repair inhibitor, monoterpene, Schiff base, tyrosyl-DNA phosphodiesterase 1, TARGET, CAMPTOTHECIN, BIOLOGICAL EVALUATION, TOP1, IDENTIFICATION, MOIETIES",
author = "Zakharenko, {A. L.} and Mozhaitsev, {E. S.} and Suslov, {E. V.} and Korchagina, {D. V.} and Volcho, {K. P.} and Salakhutdinov, {N. F.} and Lavrik, {O. I.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2018",
month = jul,
day = "1",
doi = "10.1007/s10600-018-2443-7",
language = "English",
volume = "54",
pages = "672--676",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "4",
}