Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides

S. O. Kuranov, M. E. Blokhin, S. A. Borisov, M. V. Khvostov, O. A. Luzina, N. F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Abstract: A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in the oral glucose tolerance test in mice. Amides based on (E)-3-phenylprop-2-enoic and (E)-3-(4-methoxyphenyl)prop-2-enoic acids and (2S)-cyanopyrrolidine have been shown to significantly reduce blood glucose levels in mice. The observed hypoglycemic effect at a dose of 10 mg/kg is comparable to the effect of hypoglycemic drug vildagliptin.

Язык оригиналаанглийский
Страницы (с-по)374-380
Число страниц7
ЖурналRussian Journal of Bioorganic Chemistry
Том45
Номер выпуска5
DOI
СостояниеОпубликовано - 1 сен 2019

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