Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

I. V. Il’ina; D. V. Korchagina; E. A. Morozova; T. G. Tolstikova; K. P. Volcho; N. F. Salakhutdinov

doi:10.1007/s11172-019-2520-5

Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

I. V. Il’ina, D. V. Korchagina, E. A. Morozova, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

1 Цитирования (Scopus)

Аннотация

A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

Язык оригинала	английский
Страницы (с-по)	1061-1066
Число страниц	6
Журнал	Russian Chemical Bulletin
Том	68
Номер выпуска	5
DOI	https://doi.org/10.1007/s11172-019-2520-5
Состояние	Опубликовано - 1 мая 2019

Доступ к документу

10.1007/s11172-019-2520-5

Другие файлы и ссылки

Link to publication in Scopus

Fingerprint

Подробные сведения о темах исследования «Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

@article{5c452933d60f47d592253f026654d615,

title = "Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones",

abstract = "A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.",

keywords = "analgesic activity, heterocyclic compounds, monoterpenoids, montmorillonite K10",

author = "Il{\textquoteright}ina, {I. V.} and Korchagina, {D. V.} and Morozova, {E. A.} and Tolstikova, {T. G.} and Volcho, {K. P.} and Salakhutdinov, {N. F.}",

year = "2019",

month = may,

day = "1",

doi = "10.1007/s11172-019-2520-5",

language = "English",

volume = "68",

pages = "1061--1066",

journal = "Russian Chemical Bulletin",

issn = "1066-5285",

publisher = "Springer Nature",

number = "5",

}

Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones. / Il’ina, I. V.; Korchagina, D. V.; Morozova, E. A.; Tolstikova, T. G.; Volcho, K. P.; Salakhutdinov, N. F.

В: Russian Chemical Bulletin, Том 68, № 5, 01.05.2019, стр. 1061-1066.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones

AU - Il’ina, I. V.

AU - Korchagina, D. V.

AU - Morozova, E. A.

AU - Tolstikova, T. G.

AU - Volcho, K. P.

AU - Salakhutdinov, N. F.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

AB - A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.

KW - analgesic activity

KW - heterocyclic compounds

KW - monoterpenoids

KW - montmorillonite K10

UR - http://www.scopus.com/inward/record.url?scp=85067041253&partnerID=8YFLogxK

U2 - 10.1007/s11172-019-2520-5

DO - 10.1007/s11172-019-2520-5

M3 - Article

AN - SCOPUS:85067041253

VL - 68

SP - 1061

EP - 1066

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 5

ER -