Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes

Irina Il’ina, Alla Pavlova, Dina Korchagina, Oleg Ardashov, Tat’yana Tolstikova, Konstantin Volcho, Nariman Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатья

5 Цитирования (Scopus)

Аннотация

A set of new 2-alkyl-substituted 4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols was obtained by reactions of monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aliphatic aldehydes in the presence of montmorillonite clay K10. Synthesized compounds were evaluated for their analgesic activity in vivo using the acetic acid-induced writhing test and the hot-plate test. Five compounds showed a significant analgesic activity in the acetic acid-induced writhing test; two of them also demonstrated analgesic activity in the hot-plate test. These compounds seem to be most promising for further development.

Язык оригиналаанглийский
Страницы (с-по)1415-1426
Число страниц12
ЖурналMedicinal Chemistry Research
Том26
Номер выпуска7
DOI
СостояниеОпубликовано - 1 июл 2017

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