Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

K. Yu Ponomarev, E. A. Morozova, E. V. Suslov, D. V. Korchagina, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    1 Цитирования (Scopus)

    Аннотация

    A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

    Язык оригиналаанглийский
    Страницы (с-по)1131-1136
    Число страниц6
    ЖурналChemistry of Natural Compounds
    Том53
    Номер выпуска6
    DOI
    СостояниеОпубликовано - 1 ноя 2017

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