Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

K. Yu Ponomarev; E. A. Morozova; E. V. Suslov; D. V. Korchagina; T. G. Tolstikova; K. P. Volcho; N. F. Salakhutdinov

doi:10.1007/s10600-017-2216-8

Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

K. Yu Ponomarev, E. A. Morozova, E. V. Suslov, D. V. Korchagina, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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Аннотация

A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

Язык оригинала	английский
Страницы (с-по)	1131-1136
Число страниц	6
Журнал	Chemistry of Natural Compounds
Том	53
Номер выпуска	6
DOI	https://doi.org/10.1007/s10600-017-2216-8
Состояние	Опубликовано - 1 нояб. 2017

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10.1007/s10600-017-2216-8

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abstract = "A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.",

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Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties. / Ponomarev, K. Yu; Morozova, E. A.; Suslov, E. V. и др.

В: Chemistry of Natural Compounds, Том 53, № 6, 01.11.2017, стр. 1131-1136.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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T1 - Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

AU - Ponomarev, K. Yu

AU - Morozova, E. A.

AU - Suslov, E. V.

AU - Korchagina, D. V.

AU - Tolstikova, T. G.

AU - Volcho, K. P.

AU - Salakhutdinov, N. F.

PY - 2017/11/1

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AB - A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.

KW - acetate writhing

KW - diazaadamantanes

KW - hot plate

KW - monoterpenes

KW - pain

KW - tertiary amines

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