Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2-Chromen-4,8-Diols Containing Alkyl-Substituted Aromatic Moieties

O. S. Patrusheva, A. V. Pavlova, D. V. Korchagina, T. G. Tolstikova, K. P. Volcho, N. F. Salakhutdinov

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    1 Цитирования (Scopus)

    Аннотация

    A series of new heterocyclic compounds with the hexahydro-2H-chromene skeleton were prepared by reacting the monoterpenoid para-mentha-1,8-diene-5,6-diol with 4-alkyl-substituted aromatic aldehydes. Adding small alkyl substituents (methyl and ethyl) to the aldehyde aromatic ring increased the yields of hexahydrochromenes as compared with the analogous reaction with benzaldehyde. However, adding a branched substituent (isopropyl) and longer butyl and octyl moieties reduced the yields of the target compounds. The stereoselectivity of the reaction changed as the alkyl substituent lengthened. The analgesic activity of the obtained products was studied.

    Язык оригиналаанглийский
    Страницы (с-по)1066-1071
    Число страниц6
    ЖурналChemistry of Natural Compounds
    Том53
    Номер выпуска6
    DOI
    СостояниеОпубликовано - 1 ноя 2017

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