@article{8aed000db9d044b1ad2271fe3cd7206f,
title = "Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety",
abstract = "Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro—Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established by X-ray diffraction. The conditions for the formation of furanolabdanoid arylalkyne-1,2-diones were found. The newly synthesized pyrazoles exhibit analgesic activity in a model of chemical irritation.",
keywords = "alkyne-1,2-diones, Castro—Stephens cross-coupling, diterpenoids, furanolabdanoids, heterocyclization, phenyl-hydrazines, phlomisoic acid, pyrazoles, X-ray diffraction, SERIES, YNEDIONES, CRYSTAL-STRUCTURES, ALPHA, FURANODITERPENOIDS, alkyne-1, ACETYLENIC KETONES, LAMBERTIANIC ACID, DERIVATIVES, 2-diones, TRANSFORMATIONS, Castro-Stephens cross-coupling",
author = "Mironov, {M. E.} and Poltanovich, {A. I.} and Rybalova, {T. V.} and Dolgikh, {M. P.} and Tolstikova, {T. G.} and Shults, {E. E.}",
year = "2020",
month = mar,
doi = "10.1007/s11172-020-2795-6",
language = "English",
volume = "69",
pages = "537--546",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer Nature",
number = "3",
}