Аннотация
Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.
Язык оригинала | английский |
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Страницы (с-по) | 12694-12697 |
Число страниц | 4 |
Журнал | Chemistry - A European Journal |
Том | 25 |
Номер выпуска | 55 |
DOI | |
Состояние | Опубликовано - 23 июл 2019 |