15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging

Ivan V. Skovpin, Alexandra Svyatova, Nikita Chukanov, Eduard Y. Chekmenev, Kirill V. Kovtunov, Igor V. Koptyug

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)


Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.

Язык оригиналаанглийский
Страницы (с-по)12694-12697
Число страниц4
ЖурналChemistry - A European Journal
Номер выпуска55
СостояниеОпубликовано - 23 июл 2019