Catalysts for biofuels reforming based on two types of nanocomposite active components (Ni + Ru/La0.8Pr0.2Mn0.2Cr0.8O3/Y0.08Zr0.92O2-δ, Ni + Ru/Sm0.15Pr0.15Ce0.35Zr0.35O2) supported on microchannel substrates (Ni-Al alloy foam plates, Fechraloy plates protected by a thin corundum layer) were developed. Applied procedures for the active components loading on substrates provide thermochemical stability of supported layers of active components in tough operation conditions not affecting their reactivity/catalytic activity. Effects of the nature of nanocomposite active component, type of fuel (ethanol, ethyl acetate, acetone and glycerol), feed composition and contact time on the yield of syngas/byproducts and performance stability are considered and compared with results of calculations of the equilibrium composition of reaction mixtures. For nanocomposite active components with a high oxygen mobility and reactivity, reforming of such typical fuel as ethanol is described by the step-wise red-ox mechanism. Preliminary results of the mathematical modelling of the ethanol steam reforming on a stack of microchannel Fechraloy plates loaded with Ni + Ru/Sm0.15Pr0.15Ce0.35Zr0.35O2 active component revealed that this process can be satisfactorily described by the isothermal model without any impact of the heat/mass transfer.