Stability study of the antiviral agent camphecene in dried blood spots at different temperatures

Результат исследования: Научные публикации в периодических изданияхписьмо/краткое сообщениерецензирование

Аннотация

In this study, an optimized procedure of sample preparation for quantitative determination of the antiviral agent camphecene in dried rat blood spots was developed. It has been shown that when using methanol containing 0.1% HCOOH as an extractant, the recovery of the substance increases in comparison with the previously developed method. In addition to this, there is no need to dilute the obtained solutions with water for the analysis of the sample by high-performance liquid chromatography (HPLC) on a column with a reversed-phase sorbent. By using the developed method, the stability of samples of dried rat blood spots containing camphecene in different concentrations at different temperatures was studied. It was found that while the samples were stored at room temperature, apparently, desorption of the substance occurs leading to a loss of more than 15% of its initial amount after 5–10 days. Lowering the temperature increases the stability of samples and their storage at −70°C is possible for 4 weeks.

Язык оригиналаанглийский
Страницы (с-по)1797-1802
Число страниц6
ЖурналDrug Testing and Analysis
Том13
Номер выпуска10
Ранняя дата в режиме онлайн27 авг 2021
DOI
СостояниеОпубликовано - окт 2021

Предметные области OECD FOS+WOS

  • 1.06.CQ БИОХИМИЯ И МОЛЕКУЛЯРНАЯ БИОЛОГИЯ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ
  • 3.01.TU ФАРМАКОЛОГИЯ И ФАРМАЦИЯ

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