Specifics of anaphase chromatid segregation in Drosophila melanogaster mitotic mutants

L. I. Lebedeva, S. A. Fedorova, L. V. Omelyanchuk

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Anaphase chromatid segregation defects (CSDs) were quantitatively and qualitatively studied in neural ganglion cells of third-instar larvae of several control wild type Drosophila melanogaster strains and four strains with mutations of the aar v158 , ff3, mast v40 , and CycB 2g cell cycle genes. A linear specificity was observed for the CSD frequency, type, determination, and correction probability. The probability of anaphase CSD correction was close to unity in the control strains and lower in the mutant strains. The lower correction probability in the mutant strains was explained in the context of two findings, that the mutations induced the CSDs that were atypical of the wild type strains and were potentially uncorrectable in anaphase and that the mutations negatively affected the relative anaphase time in mitosis.

Язык оригиналаанглийский
Страницы (с-по)919-927
Число страниц9
ЖурналRussian Journal of Genetics
Том44
Номер выпуска8
DOI
СостояниеОпубликовано - авг 2008

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