Riphean and Vendian terrigenous complexes are not affected by trap injections within the South-Tunguska petroliferous region and thus can be considered a priority for further prospecting for hydrocarbon accumulations. Although these strata are not exposed with wells and are not characterized by core samples, their wide distribution is proved by seismic data. The obtained data and previous paleogeographic reconstructions show similar depositional environments of terrigenous sediments for the South-Tunguska and Baikit petroliferous regions. These facts substantiate criteria for the prediction of sand reservoirs within the study area. Taking into account the complex geologic structure of the South-Tunguska petroliferous region, ambiguity of seismic data interpretation, and problems of deep-drilling technology, we provide recommendations for the geological exploration.