Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy

O. E. Redina, T. O. Abramova, L. O. Klimov, M. A. Ryazanova, L. A. Fedoseeva, S. E. Smolenskaya, N. I. Ershov, A. D. Dubinina, A. L. Markel

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key genes involved in the development of the stress-sensitive form of arterial hypertension was conducted. Our studies revealed Ephx2 gene encoding soluble epoxide hydrolase (sEH), whose transcription level was significantly higher in all the examined organs. On the basis of other studies and our previous investigations, we concluded the necessity of further studies of Ephx2 gene and an encoded sEH protein as a potential target for pharmacological treatment of stress-sensitive arterial hypertension.

Язык оригиналаанглийский
Страницы (с-по)972-981
Число страниц10
ЖурналRussian Journal of Genetics
Том53
Номер выпуска9
DOI
СостояниеОпубликовано - 1 сен 2017

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  • Цитировать

    Redina, O. E., Abramova, T. O., Klimov, L. O., Ryazanova, M. A., Fedoseeva, L. A., Smolenskaya, S. E., Ershov, N. I., Dubinina, A. D., & Markel, A. L. (2017). Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy. Russian Journal of Genetics, 53(9), 972-981. https://doi.org/10.1134/S1022795417080063