Singlet oxygen luminescence detector based on low-cost InGaAs avalanche photodiode

Alexander E. Moskalensky, Tatyana Yu Karogodina, Alexey Yu Vorobev, Sergei G. Sokolovski

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Molecular oxygen excited to singlet state (Singlet oxygen, 1O2) becomes highly reactive and cytotoxic chemical. 1O2 is commonly generated by photoexcitation of dyes (photosensitizers), including the photodynamic therapy and diagnostics of cancer. However, the formation of singlet oxygen is often unwanted for various light-sensitive compounds, e.g. it causes the photobleaching of fluorescent probes. In either case, during a development of new photosensitive chemicals and drugs there is a need to evaluate the amount of 1O2 formed during photoexcitation. The direct approach in measuring the amount of singlet oxygen is based on the detection of its luminescence at 1270 nm. However, this luminescence is usually weak, which implies the use of highly sensitive single-photon detectors. Thus the existing instruments are commonly complicated and expensive. Here we suggest an approach and report a device to measure the 1O2 luminescence using low-cost InGaAs avalanche photodiode and simple electronics. The measurements can be performed in stationary (not time-resolved) mode in organic solvents such as tetrachloromethane (CCl4), ethanol and DMSO. In particular, we performed spectral-resolved measurements of the singlet oxygen luminescence in CCl4 with the device and demonstrated high complementarity to literature data. The simple setup allows to evaluate the efficiency (or speed) of singlet oxygen generation and hence facilitates the development and characterization of new photosensitizers and other photosensitive chemicals.

Язык оригиналаанглийский
Номер статьиe00224
ЖурналHardwareX
Том10
DOI
СостояниеОпубликовано - окт. 2021

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 2 ТЕХНИКА И ТЕХНОЛОГИЯ
  • 2.11.OA ИНСТРУМЕНТЫ И ИЗМЕРИТЕЛЬНЫЕ ПРИБОРЫ.

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