Shadow coat colour in American mink associated with a missense mutation in the KIT gene

Andrey D. Manakhov, Maria Yu Mintseva, Tatiana V. Andreeva, Oleg V. Trapezov, Evgeny I. Rogaev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The classical genetic analysis describes more 35 mutations that are involved in the formation of the American mink (Neovison vison) fur colour phenotype. To date, only eight of these mutations have been linked to specific genes. Shadow is a member of the commercially valuable Black cross colour family. Here, we performed whole-genome sequencing of the American mink with a Shadow Silverblue (Sh/+ p/p) phenotype. We identified a missense mutation (c.2374 G>T) in the gene encoding the KIT proto-oncogene, receptor tyrosine kinase gene (KIT), which plays a critical role in melanogenesis as well as in the survival, growth and development of other cell types. The reported mutation results in amino acid substitution p.Asp792Tyr in a highly conserved catalytic loop of the KIT protein.

Язык оригиналаанглийский
Страницы (с-по)522-525
Число страниц4
ЖурналAnimal Genetics
Том53
Номер выпуска4
Ранняя дата в режиме онлайн28 апр. 2022
DOI
СостояниеОпубликовано - авг. 2022

Предметные области OECD FOS+WOS

  • 4.02 ЖИВОТНОВОДСТВО И МОЛОЧНОЕ ДЕЛО
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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